Seneca Village was a black enclave back in the day. It was established in what would become Central Park, around 85th Street. From there, parishioners from the “village” joined in worship with German protestants at several east side churches.
There is no evidence that this building has any affiliation with the Seneca that black landowners established. It might just have assumed the name of an ancient Roman senator.
My curiosity, however, brought me to this interesting and diverting history.
Walk with Me, Too 